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VOL. 2, ISSUE 2 (2026)
Synthesis, spectroscopic characterization, and antibacterial evaluation of Sulfathiazole-derived schiff base complexes of CO(II) and NI(II)
Authors
Ahmed Rafaa Al-jibori, Bekhal Omer Mohammed
Abstract
This study reports the synthesis, spectroscopic characterization, and
antibacterial activity of two novel Schiff base ligands and their cobalt (II)
and nickel (II) complexes. The ligands, namely L1 =
4-(2-aminobenzylideneamino)-N-(thiazol-2-yl) benzenesulfonamide and L2 =
4-(2-nitrobenzylideneamino)-N-(thiazol-2-yl) benzenesulfonamide, were prepared
via condensation reaction of sulfathiazole with two appropriate aromatic
aldehydes (2-aminobenzaldehyde and 2-nitrobenzaldehyde). The corresponding
metal complexes of the general formula [M(L)₂Cl₂] (where M = Co (II) or Ni
(II)) were subsequently synthesized. All synthesized compounds (ligands and
complexes) were characterized using a combination of physicochemical methods
including molar conductivity measurements, magnetic susceptibility, elemental
analysis (CHNS), and spectroscopic techniques such as electronic (UV-Vis)
spectroscopy, infrared (FTIR) spectroscopy, atomic absorption spectroscopy, and
proton nuclear magnetic resonance (¹H NMR). The obtained results confirmed the
proposed octahedral and tetrahedral (square planar or tetrahedral) geometries
for the prepared Schiff base complexes. The in vitro biological activity
of the free ligands and selected complexes was assessment versus two clinically
confirmed pathogenic bacterial strains: Gram-negative Escherichia coli and
Gram-positive Staphylococcus aureus. The outcomes revealed that the metal
complexes exhibit significantly higher inhibitory activity compared to their
parent free ligands, with complexes designated as (C1, C2, N1, N2) showing the
most potent antibacterial effects.
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Pages:56-64
How to cite this article:
Ahmed Rafaa Al-jibori, Bekhal Omer Mohammed "Synthesis, spectroscopic characterization, and antibacterial evaluation of Sulfathiazole-derived schiff base complexes of CO(II) and NI(II)". International Journal of Applied Review
, Vol 2, Issue 2, 2026, Pages 56-64
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