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VOL. 1, ISSUE 1 (2025)
The effect of robusta coffee supplementation on blood fibrinogen in high-fat diet-induced Rats
Authors
Rendra Christedy Prasetya
Abstract
This study investigates
the impact of Robusta coffee supplementation on blood fibrinogen levels in rats
subjected to a high-fat diet (HFD). Elevated blood fibrinogen is a known risk
factor for cardiovascular diseases, often associated with obesity and
hyperlipidemia induced by high-fat diets. Robusta coffee, rich in bioactive
compounds such as caffeine, chlorogenic acids, and antioxidants, has been
proposed to exert beneficial effects on metabolic and inflammatory parameters.
In this experimental study, male Wistar rats were divided into control and HFD
groups, with the latter receiving different doses of Robusta coffee
supplementation over eight weeks. Blood fibrinogen levels were measured to
assess the prothrombotic state induced by HFD and the potential modulatory
effect of coffee intake. Results demonstrated that rats fed with a high-fat
diet exhibited significantly elevated fibrinogen levels compared to controls,
confirming the diet-induced pro-inflammatory and pro-coagulant state.
Supplementation with Robusta coffee significantly reduced blood fibrinogen
concentrations in a dose-dependent manner, suggesting its protective role
against HFD-induced hypercoagulability. These findings support the potential
use of Robusta coffee as a dietary supplement to mitigate cardiovascular risk
factors associated with high-fat diet consumption. Further studies are
warranted to elucidate the underlying mechanisms and translate these findings
to clinical settings.
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Pages:14-18
How to cite this article:
Rendra Christedy Prasetya "The effect of robusta coffee supplementation on blood fibrinogen in high-fat diet-induced Rats". International Journal of Applied Review
, Vol 1, Issue 1, 2025, Pages 14-18
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